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Health and Safety Report

Titanium Nanoparticle 
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Element 1: Titanium
Structure: Spherical
Origin: Other
PPMD: 7  nm
Added to NIL: 3/3/2005 10:22:00 PM
Contributor: Colin   R   Pulham  ,   University of Edinburgh 

Note: Listed below are links to databases which may contain information pertinent to this type of nanoparticle.
Nano Material Info Bulk Material Info
Nano MSDS:
[Not known at this time]

Nano Exposure Limits:
[Not known at this time]

Nano Toxicity:
However, these nanoparticles inhalation can induce pulmonary toxicity and its mechanism is not fully understood. NanoTiO2 can induce pulmonary emphysema, macrophages accumulation, extensive disruption of alveolar septa, type II pneumocyte hyperplasia, and epithelial cell apoptosis. In particular, nanoTiO2 up-regulates placenta growth factor (PlGF) and other chemokines (CXCL1, CXCL5, and CCL3) expressions that may cause pulmonary emphysema and alveolar epithelial cell apoptosis. Cultured human THP-1 cell-derived macrophages treated with nanoTiO2 in vitro also resulted in up-regulations of PlGF, CXCL1, CXCL5, and CCL3. These results indicated that nanoTiO2 can induce severe pulmonary emphysema, which may be caused by activation of PlGF and related inflammatory pathways (Abstract Truncated) For complete ICON abstract

Chemical used in synthesis (1)
Material used in synthesis
Bulk Exposure Limits:
[See NIOSH Pocket Guide]
Pocket Guide for Titanium

Bulk Toxicity:
No RTECS listed for Potassium Hexamethyldisilazide
RTECS for Titanium

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